Gaucher's disease is caused by an accumulation of glucocerebrosides (glucosylceramide) in macrophages. The specific enzyme deficiency is glucocerebrosidase (acid beta-glucosidase, lysosomal enzyme ...

Clinical research is conducted to generate unbiased data, to improve existing knowledge, and to generate results valid for the majority of patients. To achieve these goals, clinical researchers mus ...

Osteoporosis is the most common metabolic bone disease and is characterized by low bone mass and microarchitectural deterioration of the bone tissue. A normal mineral:collagen ratio is pr ...

The human genome is composed of 30,000 unique genes. Each gene is composed of a promotor or regulator region, and a transcriptional or coding region. Regulatory proteins or transcription factors bi ...

Hyperparathyroidism is a condition which is caused by excessive amounts of parathyroid hormone (PTH). The primary etiologies of hyperparathyroidism are, in decreasing order, adeno ...

A new era of orthopedic surgery has been marked by gene therapy, an approach that provides options for treating patients with orthopedic conditions. Orthopedic surgeons must understand the terminol ...

Rickets (youth) and osteomalacia (adult) result from the failure to mineralize epiphyseal cartilage, which increases the hypertrophic zone, and bone, which decreases the mineralization rate and inc ...

The human genome is composed of 30,000 unique genes. Each gene is composed of a promotor or regulator region, and a transcriptional or coding region. Regulatory proteins or transcription factors bi ...

Galvanic corrosion is caused by an electrochemical potential that is created between two metals that are located in a conductive environment, such as body fluids. Examples of galvanic co ...

The term biomaterials is generally used to refer to synthetic materials used temporarily or permanently to augment or replace tissues and their functions. However, the most importa ...